2024
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models
Puray-Chavez M, LaPak KM, Jasuja R, Pan J, Xu Jian, Eschbach JE, Mohammed S, Lawson DQ, Wang Q, Brody SL, Major BM, Goldfarb D, Kutluay SB
BioRxiv, 2024
2023
Poly-basic peptides and polymers as new drug candidate against Plasmodium falciparum
Sivakumar R, Floyd K, Jessey E, Kim JK, Bayguinov P, Fitzpatrick PAJ, Goldfarb D, Jovanovic M, Tripathi A, Djuranovic S, Pavlovic-Djuranovic S
BioRxiv, 2023
Biophysical mechanism of allosteric regulation of actin capping protein.
Mooren OL, Stuchell-Brereton MS, McConnell P, Yan C, Wilkerson EM, Goldfarb D, Cooper JA, Sept D, Sorrano A
Journal of Molecular Biology, 2023
Protein kinase signaling networks driven by oncogenic Gq/11 in uveal melanoma identified by phosphoproteomic and bioinformatic analyses
Onken MD, Erdmann-Gilmore P, Zhang Q, Thapa K, King E, Kaltenbronn KM, Noda SE, Makepeace CM, Goldfarb D, Babur O, Townsend RR, Blumer KJ
Molecular and Cellular Proteomics, 2023
Targeted Proteomics quantitation of NRF2 signaling and predictive biomarkers in HNSCC
Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zokind P, Le QT, Goldfarb D*, Major MB*
Molecular and Cellular Proteomics, 2023
Structural basis of paralog-specific KDM2A/B nucleosome recognition
Spangler CJ, Skrajna A, Foley CA, Nguyen A, Budziszewski GR, Azzam DN, Arteaga EC, Simmons HC, Smith CB, Wesley NA, Wilkerson EM, McPherson JME, Kireev D, James LI, Frye SV, Goldfarb D, McGinty RK
Nature Chemical Biology, 2023
2022
Enabling hotspot detection and public health response to the COVID-19 pandemic
Foraker R, Landman J, Lackey I, Haslam MD, Antes AL, Goldfarb D
Preventing Chronic Disease, 2022
Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveals unique roles for CK1γ3 in WNT signaling
Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, Major MB
Journal of Biological Chemistry, 2022
Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract
Zhang J, Morgan EW, Sanidad KZ, Zhang H, Liang Y, Zhao E, Chacon-Vargas K, Yeliseyev V, Parsonnet J, Haggerty TD, Wang G, Simpson JB, Jariwala PB, Beaty VV, Yang J, Yang H, Panigrahy A, Minter LM, Kim D, Gibbons JG, Liu L, Li Z, Xiao H, Borlandelli V, Overkleeft HS, Cloer EW, Major MB, Goldfarb D, Cai Z, Redinbo MR, Zhang G
Nature Communications, 2022
2021
Visualizing an allosteric intermediate using CuAAC stabilization of an NMR mixed labeled dimer
Sapienza P, Currie M, Lancaster N, Li K, Aubé J, Goldfarb D, Cloer E, Major MB, Lee A
ACS Chemical Biology, 2021
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
Chavez-Puray M, LaPak KM, Schrank TP, Elliott JL, Bhatt DP, Agajanian MJ, Jasuja R, Lawson DQ, Davis K, Rothlauf PW, Jo H, Lee N, Tenneti K, Eschbach JE, Mugisha CS, Vuong HR, Bailey AL, Hayes DN, Whelan SPJ, Horani A, Brody SL, Goldfarb D, Major MB, Kutluay SB
Cell Reports, 2021
TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47
Urbina LF, Menon S, Goldfarb D, Edwards R, Major MB, Brennwald P, Gupton S
Cell Reports, 2021
The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis
Menon S, Goldfarb D, Ho T, Cloer EW, Boyer N, Hardie C, Bock A, Johnson E, Anil J, Major MB, Gupton S
Molecular Biology of the Cell, 2021
2020
The ubiquitylome of developing cortical neurons
Menon S, Goldfarb D, Cousins EM, Major MB, Gupton S
microPublication Biology, 2020
The Dark Kinase Knowledgebase: An Online Compendium of Knowledge and Experimental Results of Understudied Kinases
Berginski M, Moret N, Liu C, Goldfarb D, Sorger P, Gomez, S
Nucleic Acids Research, 2020
Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding
Skrajna A, Goldfarb D, Kedziora K, Cousins E, Grant G, Anderson C, Barbour E, Yan X, Hathaway N, Brown N, Cook J, Major MB, McGinty R
Nucleic Acids Research, 2020
Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor
Tamir TY, Bowman BM, Agajanian MJ, Goldfarb D, Schrank TP, Stohrer T, Hale AE, Siesser PF, Weir SJ, Murphy RM, LaPak KM, Weissman BE, Moorman NJ, Major MB
Journal of Cell Science, 2020
Wnt Regulation: Exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex
Schaefer KN, Pronobis M, Williams CE, Bauer L, Goldfarb D, Yan F, Major MB, and Peifer M
Biology of the Cell, 2020
Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells
McDonald IM, Grant GD, East MP, Gilbert TSK, Wilkerson EM, Goldfarb D, Beri J, Herring LE, Vaziri C, Cook JG, Emanuele M, and Graves LM
Journal of Biological Chemistry, 2020
Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling
Jariwala P, Pellock S, Goldfarb D, Cloer E, Artola M, Simpson J, Bhatt A, Walton W, Roberts L, Major M, Davies G, Overkleeft HS, Redinbo M
ACS Chemical Biology, 2020
2019
PepSAVI-MS Reveals Proline-rich Antimicrobial Peptide in Amaranthus tricolor
Moyer T, Heil L, Kirkpatrick C, Goldfarb D, Lefever W, Parsley N, Wommack A, Hicks L
Journal of Natural Products, 2019
Positive cooperativity in substrate binding by human thymidylate synthase
Bonin JP, Sapienza PJ, Wilkerson E, Goldfarb D, Wang L, Herring L, Chen X, Major MB, Lee AL
Biophysical Journal, 2019
NRF2 activation in cancer: from DNA to protein
Cloer EW, Goldfarb D, Schrank TP, Weissman BE, Major MB.
Cancer Research, 2019
2018
Dasatinib is preferentially active in the activated B-cell subtype of diffuse large B-cell lymphoma
Cann ML, Herring LE, Gilbert TSK, Goldfarb D, Richards KL, Graves LM, Lawrence DS
Journal of Proteome Research, 2018
Approximating isotopic distributions of biomolecule fragments
Goldfarb D, Lafferty M, Herring LE, Wang W, Major MB
ACS Omega, 2018
p62-dependent phase separation of patient-derived KEAP1 mutations and NRF2
Cloer EW, Siesser PF, Cousins EM, Goldfarb D, Weir SJ, Mowrey DD, Harrison JS, Dokholyan NV, Major MB
Molecular and Cellular Biology, 2018
2017
Competitive kinase enrichment proteomics reveals that Abemaciclib inhibits GSK3β and activates Wnt signaling
Cousins EM, Goldfarb D, Yan F, Roques J, Darr D, Johnson GJ, Major MB
Molecular Cancer Research, 2017
2016
Identification and characterization of MCM3 as a Kelch-like ECH-associated protein 1 (KEAP1) Substrate
Mulvaney KM, Matson JP, Siesser PF, Tamir TY, Goldfarb D, Jacobs T, Cloer EW, Harrison JS, Vaziri C, Cook JG, Major MB
Journal of Biological Chemistry, 2016
Hemi-methylated DNA regulates DNA methylation inheritance through allosteric control of H3 ubiquitylation by UHRF1
Harrison JS, Cornett EM, Goldfarb D, Darosa PA, Li ZZ, Yan F, Dickson BM, Guo AH, Cantu DV, L, Brown PJ, Arrowsmith CH, Klevit RE, Erie DA, Major MB, Krajewski K, Kuhlman B, Strahl BD, and Rothbart SB
Elife, 2016
A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis
Gao Y, Mutter-Rottmayer E, Greenwalt AM, Goldfarb D, Yan F, Yang Y, Martinez-Chacin RC, Pearce KH, Tateishi S, Major MB and Vaziri C
Nature Communications, 2016
2015
MSAcquisitionSimulator: data-dependent acquisition simulator for LC-MS shotgun proteomics
Goldfarb D, Wang W, Major MB
Bioinformatics, 2015
FOXP1 potentiates Wnt/Beta-Catenin signaling in diffuse large B cell lymphoma
Walker MP, Stopford CM, Cederlund M, Fang F, Jahn C, Rabinowitz AD, Goldfarb D, Graham DM, Yan F, Deal AM, Fedoriw Y, Richards KL, Davis IJ, Weidinger G, Damania B, and Major MB
Science Signaling, 2015
2014
Substrate trapping proteomics reveals targets of the BTrCP2/FBXW11 ubiquitin ligase
Kim TY, Siesser PF, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss MJ, Moon RT, Der CJ, and Major MB
Molecular and Cellular Biology, 2014
Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification – mass spectrometry data
Goldfarb D, Hast BE, Wang W, Major MB
Journal of Proteome Research, 2014
SNF5/INI1 deficiency redefines chromatin remodeling complex composition during tumor development
Wei D, Goldfarb D, Song S, Cannon C, Yan F, Sakellariou-Thompson D, Emanuele M, Major MB, Weissman BE, and Kuwahara Y
Molecular Cancer Research, 2014
New insights from proteomic analysis of Wnt signaling
Walker MP, Goldfarb D, Major MB
Wnt Signaling in development and disease, Chapter 10, 2014
2013
Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination
Hast BE, Cloer EW, Goldfarb D, Li H, Siesser PF, Yan F, Walter V, Zheng N, Hayes DN, Major MB
Cancer Research, 2013
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination
Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, and Major MB
Cancer Research, 2013
2012
FAM123A binds microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility
Siesser PF, Motolese M, Walker MP, Goldfarb D, Gewain K, Yan F, Kulikaukas RM, Chien AJ, Wordeman L, and Major MB
Science Signaling, 2012
2009
MetPetDB: A database for metamorphic geochemistry
Spear FS, Hallett B, Pyle JM, Adali S, Szymanski BK, Waters A, Linder Z, Pearce SO, Fyffe M, Goldfarb D, Glickenhouse N, Buletti H
Geochemistry, Geophysics, Geosystems, 2009